Book a room close to the Inner Harbor, in an international chain hotel that’s anything but generic. Kimpton takes great care to ensure each of its properties reflect the local area and its heritage. And their Baltimore property —an impressive restored 1906 Beaux Arts building, the former headquarters of B&O Railroad — retains all of its period elegance, along with some complimentary, bold, 21st-century colours. Bedrooms here include Frette linens, gourmet honour bars, Bigelow toiletries and work desks. Dine onsite at the excellent B&O American Brasserie, or try out some of the seafood options on the doorstep.