This 16th-century palace is now part of the slick and contemporary NH Collection. It’s an ideal choice for those wishing to escape the throng, yet still within walking distance of the main attractions, as it’s located in the peaceful residential quarter of Sestiere Cannaregio, surrounded by an 18th-century botanical garden. And when you do want a slice of the action, you can easily take a boat trip from the hotel’s private pier, or hop on the complimentary shuttle. 64 Venetian-style rooms are accommodated over five floors, along with its Il Giardino Segreto and La Loggia restaurants and La Voga Bar.