Best Luxury Hotels in Panama City

Strategically positioned in Panama City’s bustling financial district, Hyatt Regency Panama City offers a seamless blend of business convenience and cultural discovery. The hotel features 382 rooms and suites, each styled with carved wood furnishings and green marble details that reflect Panamanian artistry. Business travellers benefit from work-friendly amenities and access to the Regency Club Lounge, which offers complimentary breakfast and evening hors d’oeuvres. The ground-level pool and 24-hour fitness centre provide welcome relaxation after meetings or city exploration. Guests are just a short drive from cultural highlights like the UNESCO-listed Casco Viejo, the Biodiversity Museum, and the vibrant culinary and nightlife scenes of Panama City.

Dining includes Rulfo, an all-day restaurant that transitions into a lively cervecería, and Amado, a cosy café serving speciality coffees and light bites. Two additional venues, Belisario wine bar and Refugio speakeasy, are set to open in late 2025. With 25,000 sq ft of event space, including a Regency Ballroom, 12 meeting rooms, and an outdoor terrace, the hotel is well-equipped for both corporate functions and celebrations.

Housed in a 50-storey building, W is the epitome of contemporary glamour. Make a splash at the Wet Deck on the 15th floor, where you can lounge on a daybed cocktail in hand and gaze out to the skyscraper horizon. Dance and drink to the sounds of live music and DJs at La Cajita, hang out in the Tetris-like Living Room which looks like a funky modern art installation and eat Spanish-inspired cuisine with epic views through the full-height windows at Moro. 203 guestrooms feature white-lacquered furniture, high-contrast design elements, graffiti artwork and bright colours for a playful, VIP-worthy effect. Book the Extreme Wow suite for your own DJ booth and party lounge with a built-in foosball table.

This urban resort is centred around a sprawling pool with an open-air bar, loungers and palm trees. A treat for golfers, it includes an 18-hole, par-72 Jack Nicklaus-designed championship golf course. The hotel spa has been inspired by indigenous culture and there are three on-site restaurants; Mestizo with its bar, terrace and outdoor plaza, The Grill House FSH & STK and Aqva with a relaxed indoor-outdoor vibe and hanging chairs. The Santa Maria also has a chic deli to grab some food and drink before your day of exploring. Your bedroom will come with Le Chemin amenities, a fully stocked mini-bar and a NESCAFE® Dolce Gusto coffee machine.

Book a room overlooking the waterfront in a UNESCO World Heritage Site, at Sofitel Legend Casco Viejo (the sixth property to join the brand’s portfolio). Once Panama’s Union Club (visited by monarchs and icons), this is a building synonymous with culture and local heritage. Now it’s been made over as a 159-bedroom hotel, set around a huge pool and sun terrace that’s arranged over two storeys. It opened in the third quarter of 2022, with five restaurants led by a Michelin-starred chef, plus the Ammi SkyBar and a spa incorporating tea and relaxation rooms.